Publication

Full publication list : Google Scholar, ORCID

+ equal contribution, * corresponding

• Hojun Jung+, Bada Jeong+, Yong-Woo Kim+, Chanju Jung, Heesoo Uhm, Hyoungrak Kim, Ye Eun Oh, Yoonseo Park, Yeji Lee, Sangsu Bae*, "Site-specific replacement of large-scale DNA fragments in human cells", (Submitted) bioRxiv

• Hyeon Woo Im, Bada Jeong, Yeji Lee, Ye Eun Oh, Chanju Jung, Yong-Woo Kim, Heesoo Uhm, Sangsu Bae*, "Engineered ADARs enable single-nucleotide resolution DNA A-to-G editing without bystander effects", (Submitted) bioRxiv

• Jihyeon Yu+, Ju-Chan Park+, Heesoo Uhm, Yong-Woo Kim, Hyeon Woo Im, Sangsu Bae*, "Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity", Advanced Science, 2026

• Heesoo Uhm, Sangsu Bae*, "Expansion of artificial intelligence for genome editing", Nature Structural & Molecular Biology, 2025

• Ju-Chan Park+, Heesoo Uhm+, Yong-Woo Kim, Ye Eun Oh, Jang Hyeon Lee, Jiyun Yang, Kyoungmi Kim, Sangsu Bae*, "AI-generated MLH1 small binder improves prime editing efficiency", Cell, 2025

• Eunho Song, Sun Han, Heesoo Uhm, Changwon Kang*, Sungchul Hohng*, "Single-mode termination of phage transcriptions, disclosing bacterial adaptation for facilitated reinitiations", Nucleic Acids Research, 2024

• Eunho Song, Heesoo Uhm, Palinda Ruvan Munasingha, Seungha Hwang, Yeon-Soo Seo, Jin Young Kang*, Changwon Kang*, Sungchul Hohng*, "Rho-dependent transcription termination proceeds via three routes", Nature Communications, 2022

• Abhishek Mazumder*, Anna Wang, Heesoo Uhm, Richard H Ebright, Achillefs N Kapanidis*, "RNA polymerase clamp conformational dynamics: long-lived states and modulation by crowding, cations, and nonspecific DNA binding", Nucleic Acids Research, 2021

• Soochul Shin+, Yoonseok Jung+, Heesoo Uhm, Minseok Song, Soomin Son, Jiyoung Goo, Cherlhyun Jeong, Ji-Joon Song, V Narry Kim, Sungchul Hohng*, "Quantification of purified endogenous miRNAs with high sensitivity and specificity", Nature Communications, 2020

• Wooyoung Kang+, Kook Sun Ha+, Heesoo Uhm, Kyuhyong Park, Ja Yil Lee, Sungchul Hohng*, Changwon Kang*, "Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA", Nature Communications, 2020

• Heesoo Uhm, Sungchul Hohng*, "Single-molecule FRET assay for studying cotranscriptional RNA folding", RNA Chaperones: Methods and Protocols, 2019 (PDF)

• Mina Lee+, Soochul Shin+, Heesoo Uhm+, Heesun Hong, Jaewon Kirk, Kwangbeom Hyun, Tomasz Kulikowicz, Jaehoon Kim, Byungchan Ahn*, Vilhelm A Bohr*, Sungchul Hohng*, "Multiple RPAs make WRN syndrome protein a superhelicase", Nucleic Acids Research, 2018

• Heesoo Uhm, Wooyoung Kang, Kook Sun Ha, Changwon Kang, Sungchul Hohng*, "Single-molecule FRET studies on the cotranscriptional folding of a thiamine pyrophosphate riboswitch", Proceedings of the National Academy of Sciences, 2018

• Heesoo Uhm, Sungchul Hohng*, "Ligand recognition mechanism of thiamine pyrophosphate riboswitch aptamer", Bulletin of the Korean Chemical Society, 2017 (PDF)

• Nam-Kyung Yu+, Heesoo Uhm+, Jaehoon Shim+, Jun-Hyeok Choi, Sangsu Bae, Todd Charlton Sacktor, Sungchul Hohng*, Bong-Kiun Kaang*, "Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors", Molecular Brain, 2017

• Heesoo Uhm, Sangsu Bae, Mina Lee, Sungchul Hohng*, "Single-Molecule FRET Combined with Magnetic Tweezers at Low Force Regime", Bulletin of the Korean Chemical Society, 2016 (PDF)